Clonal tracing with somatic epimutations reveals dynamics of blood ageing

by | May 21, 2025 | Uncategorized | 0 comments

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Nature, Published online: 21 May 2025; doi:10.1038/s41586-025-09041-8

The discovery that DNA methylation of different CpG sites can serve as digital barcodes of clonal identity led to the development of EPI-Clone, an algorithm that enables single-cell lineage tracing through cellular differentiation at scale.

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