Unravelling cysteine-deficiency-associated rapid weight loss

by | May 21, 2025 | Uncategorized | 0 comments

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Nature, Published online: 21 May 2025; doi:10.1038/s41586-025-08996-y

Conditional cysteine restriction in mice causes substantial weight loss, exceeding that seen with essential amino acid restriction, by activating the integrated stress and oxidative stress responses, and by unexpectedly depleting coenzyme A, leading to metabolic inefficiency.

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